What the labels say about sites
The instructions are short and consistent across the weekly injections:123
- Inject under the skin (subcutaneously) of the abdomen, thigh or upper arm.
- Rotate injection sites with each dose. The tirzepatide patient information adds that you may use the same area of the body, but should choose a different site within it.
- The patient instructions ask you to keep at least 2 inches (5 cm) from the belly button.
- For tirzepatide, the instructions say another person should give injections in the back of the upper arm.
- Do not inject into the same site used for another medicine, and never into a muscle or vein.
Why rotate? The tirzepatide instructions give the reason directly: changing the site within the area you choose reduces the risk of lipodystrophy (pitted or thickened skin) and localised cutaneous amyloidosis (skin with lumps) at injection sites.2 Site does not change how much medicine you get — both labels report similar exposure whichever of the three areas is used.12
How to use the chart
- Pick an order — for example 1, 2, 3, 4 around the abdomen, then 5 and 6 on the thighs — and stick to it. An order you do not have to think about is an order you will keep.
- Log every injection with the date and zone number. With a weekly injection, 16 rows is about four months.
- Note anything unusual at a site — redness, itching, bruising or a lump — so you can avoid that spot and mention it if it persists.
- Follow your own medicine's instructions if they differ, and ask your prescriber or pharmacist which sites suit you.
Skin reactions at the injection site are listed on the labels — for tirzepatide in 6% to 8% of people against 2% on placebo.2 Most are minor; see injection-site reactions for what is common and when to get one checked.
Common questions
Where can you inject GLP-1 medicines?
Does the injection site change how well it works?
Can I use the same area every week?
Sources
- Semaglutide injection and tablets for weight management — US prescribing information DailyMed, US National Library of Medicine, version published 30 June 2026
- Tirzepatide injection for weight management and obstructive sleep apnoea — US prescribing information DailyMed, US National Library of Medicine, version published 2 September 2026
- Dulaglutide injection — US prescribing information DailyMed, US National Library of Medicine, version published 10 August 2026
Written by the Cafeity team from the sources listed here. Figures from prescribing information are quoted as the label states them; trial results are averages from those trials, not predictions for any one person. This page has not yet been reviewed by a clinician — see the editorial policy for how pages are researched and corrected.
